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New study reveals positive long-term impact of switching from cigarettes to glo™

PRESS RELEASE

06 SEPTEMBER 2022

New study reveals positive long-term impact of switching from cigarettes to glo™

  • New one-year data showed smokers who switched exclusively to glo achieved significant and sustained improvements in several indicators of potential harm compared to those who continued to smoke
  •  Study results add to the weight of evidence that supports glo as a reduced-risk* product
  •  Results reinforce BAT’s commitment to Tobacco Harm Reduction and its ability to deliver A Better Tomorrow™ by reducing the health impact of its business
     

The full results  from a year-long study showed that smokers switching exclusively to glo, BAT’s flagship Tobacco Heating Product (THP), achieved significant and sustained improvements in several indicators of potential harm associated with early disease development compared to smokers who continued to smoke. This included lung disease, cancer, and cardiovascular disease (CVD).

The full results, which were published in Internal and Emergency Medicine i, build upon the favourable changes reported   at three and six-months. The improvements observed were sustained over the 12 months of the study, adding to the weight of evidence that supports glo as a less risky* alternative for adult smokers who would not otherwise quit.ii,iii

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Dr David O’Reilly, Director, Scientific Research at BAT, said: “The results from this study are the most important data we have ever generated about glo and for the THP category in general. This real-world study allows us to assess the changes that adult smokers switching exclusively to glo experience, by assessing early indicators of potential harm associated with disease development. It provides much needed new evidence about the size of the change and durability of the effect switching completely to glo can have, and reinforces glo’s potential as a reduced-risk product*.

“I’d like to thank everyone who participated in and helped deliver this study. It is another important step forward in our journey to building A Better Tomorrow.”

Based on the early indicators of disease measured, smokers who switched completely to glo instead of continuing to smoke showed:

  •  Significant and sustained reduction in a biomarker with the potential to cause DNA damage associated with lung cancer
  •  Significant and sustained reduction in white blood cell count, an inflammatory marker associated with early development of CVD and other smoking-related diseases
  •  Sustained improvement in HDL cholesterol associated with reduced development of CVD
  •  Significant and sustained improvement in an indicator of lung health (FeNO)
  •  Significant and sustained improvement in a key indicator of oxidative stress, a process implicated in several smoking-related diseases, such as CVD

These new data build on the findings of another recent publication about gloiiii, which concluded that “given the accumulated scientific data, glo is a reduced exposure product compared to combustible cigarettes and is reasonably deemed to reduce the risk of smoking-related diseases and supports the conclusion that smokers who switch entirely to THP glo use, will reduce their relative risk of developing smoking-related diseases as compared to continued smoking.”

About this study


Participants in this year-long randomised controlled study were UK-based smokers aged 23 to 55 in good general health. The smokers who did not intend to quit were randomised to either continue smoking cigarettes or switched to using only glo, while smokers who indicated they wanted to stop smoking were offered nicotine replacement therapy and access to a cessation counsellor. A group of ‘never smokers’ was also included to act as a control group and continued not to use any tobacco or nicotine products.

This study was designed to explore the risk reduction potential of glo when used in a real-world setting rather than in a clinical setting. Participants were required to attend monthly clinic visits, where samples of blood, urine and other measurements were taken. These samples were tested for “biomarkers of exposure” (to selected cigarette smoke toxicants) and “biomarkers of potential harm”. In addition, to ensure those in the study who had stopped or switched were not also using cigarettes, the glo and cessation groups were tested for the biomarker, CEVal, which can indicate if they have smoked cigarettes. Those who tested positive continued to participate in the study, and the final results were divided into the total population and a subset who were CEVal compliant, which ensured the results accurately reflect the impact of completely switching.

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* Based on the weight of evidence and assuming a complete switch from cigarette smoking. These products are not risk free and are addictive.
† Our products as sold in the US, including Vuse, Velo, Grizzly, Kodiak, and Camel Snus, are subject to Food and Drug Administration (FDA) regulation and no reduced-risk claims will be made as to these products without FDA clearance.

i Gale N, McEwan M, Hardie G et al (2022) Changes in biomarkers of exposure and biomarkers of potential harm after 360 days in smokers who either continue to smoke, switch to a tobacco heating product or quit smoking. Intern Emerg Med. https://doi.org/10.1007/s11739-022-03062-1

ii Gale N, McEwan M, Camacho OM et al (2021) Changes in biomarkers of exposure on switching from a conventional cigarette to the glo tobacco heating product: a randomized, controlled ambulatory study. Nicotine Tob Res 23(3):584–591. https://doi.org/10.1093/ntr/ntaa135
iii Gale N, McEwan M, Camacho OM et al (2021) Changes in biomarkers after 180 days of tobacco heating product use: a randomised trial. Intern Emerg Med 16:2201–2212. https://doi.org/10.1007/s11739-021-02798-6
iiii Goodall S, Gale N, Thorne D, Hadley S, Prasad K, Gilmour I, Miazzi F, Proctor C, (2022) Evaluation of behavioural, chemical, toxicological and clinical studies of a tobacco heated product glo™ and the potential for bridging from a foundational dataset to new product iterations. Toxicology Reports. https://doi.org/10.1016/j.toxrep.2022.06.014.

Forward-looking statements


This release contains certain forward-looking statements, including "forward-looking" statements made within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. These statements are often, but not always, made through the use of words or phrases such as "believe," "anticipate," "could," "may," "would," "should," "intend," "plan," "potential," "predict," "will," "expect," "estimate," "project," "positioned," "strategy," "outlook", "target" and similar expressions. These include statements regarding our customer target ambition, New Categories revenue targets and our ESG targets.

All such forward-looking statements involve estimates and assumptions that are subject to risks, uncertainties and other factors. It is believed that the expectations reflected in this release are reasonable but they may be affected by a wide range of variables that could cause actual results to differ materially from those currently anticipated. A review of the reasons why actual results and developments may differ materially from the expectations disclosed or implied within forward-looking statements can be found by referring to the information contained under the headings “Cautionary Statement” and "Group Principal Risks " in the 2021 Annual Report and Form 20-F of British American Tobacco p.l.c. (BAT).

Additional information concerning these and other factors can be found in BAT's filings with the U.S. Securities and Exchange Commission ("SEC"), including the Annual Report on Form 20-F and Current Reports on Form 6-K, which may be obtained free of charge at the SEC's website, http://www.sec.gov and BAT’s Annual Reports, which may be obtained free of charge from the BAT website www.bat.com.

Past performance is no guide to future performance and persons needing advice should consult an independent financial adviser. The forward-looking statements reflect knowledge and information available at the date of preparation of this release and BAT undertakes no obligation to update or revise these forward-looking statements, whether as a result of new information, future events or otherwise. Readers are cautioned not to place undue reliance on such forward-looking statements.